Submit a Protocol

Use Cayuse for all IRB applications

The Purdue HRPP/IRB utilizes the cloud-based system, Cayuse IRB for protocol submission. Login to Cayuse with your BoilerKey (preferred browser is Google Chrome) at

Use this Quick Reference Guide to submit a new study to the IRB. New users will need to be added to Cayuse IRB. Please fill out the quick form here. We will establish your account within 48 business hours of the request. Once you have an account, you will not need to request access again. Please know that all user accounts must be established with valid Purdue University career account credentials.

To modify, renew, or close a previously approved (legacy) protocol, please see the instructions on this page.

Respond to IRB Revision Requests

Please respond promptly to the IRB with any requests for protocol revisions. The Cayuse system allows you to make edits in line with the protocol.

To address revisions, please follow the directions found here.

What can I do to speed up the processing of my submission?

The use of the Cayuse IRB system is anticipated to assist in the processing time of applications. Here are some additional tips to help researchers prepare their submission.

  • Be certain that all key personnel on the study have completed required training before submitting an IRB protocol.
  • Check recent updates and metrics to help anticipate the standard approval times.
  • Utilize the Purdue IRB Training and Tools page to find researcher guides and information you can use to develop your protocols. This will also give you the dates and times for upcoming in-person training sessions.
  • Contact us in advance. Our Chairs, Administrator, and Protocol Analysts will schedule virtual appointments to assist research teams. (Please see the Virtual Appointment Guidelines first.)

Purdue University, West Lafayette, IN 47907 (765) 494-4600

© 2024 Purdue University | An equal access/equal opportunity university | Copyright Complaints | Maintained by Office of the Research

If you have trouble accessing this page because of a disability, please contact Office of Research at